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HY-12071A LDN193189鹽酸鹽（的同義詞LDN193189鹽酸鹽; LDN-193189鹽酸鹽）機制：ALK

LDN193189鹽酸鹽技術(shù)參數(shù)：價格和可用性LDN193189鹽酸鹽

LDN193189鹽酸鹽M.Wt：442.94

LDN193189鹽酸鹽分子式：C25H23ClN6

LDN193189的鹽酸純度：>98％

LDN193189鹽酸貯存：貯存在-20℃2年

LDN193189鹽酸鹽CAS號：1062368-62-0

LDN193189鹽酸鹽溶解性：DMSO

生物活性LDN193189鹽酸：

LDN193189是一種高度有效的小分子BMP抑制劑;抑制BMP I型受體ALK2（IC50：nM的5個），ALK3（IC50：30納米）和ALK6（TGFβ1/BMP信令）和隨后的SMAD蛋白的磷酸化; LDN193189是有用的工具中的干細胞生物學(xué)。 LDN193189顯示在體內(nèi)的臨床應(yīng)用價值，抑制FOP和異位骨化和潛在的代理人在治療非小細胞肺癌肺腫瘤具有重要意義。

HY-12071A  LDN193189 hydrochloride (Synonyms  LDN 193189 hydrochloride; LDN-193189 hydrochloride)   Mechanisms:ALK 
LDN193189 hydrochloride M.Wt: 442.94
LDN193189 hydrochloride Formula: C25H23ClN6
LDN193189 hydrochloride Purity: >98%
LDN193189 hydrochloride Storage: at -20℃ 2 years
LDN193189 hydrochloride CAS No.: 1062368-62-0
LDN193189 hydrochloride Solubility: DMSO     
5mg
10mg
50mg
Biological Activity of LDN193189 hydrochloride: 
LDN193189 is a highly potent small molecule BMP inhibitor; inhibiting BMP type I receptors ALK2 (IC50: 5 nM), ALK3 (IC50: 30 nM) and ALK6 (TGFβ1/BMP signaling) and subsequent SMAD phosphorylation; LDN193189 is useful tool in stem cell biology. LDN193189 shows significant in vivo clinical utility, inhibiting FOP and ectopic ossification and a potential agent in the treatment of NSCLC lung tumors.