CBP73253 | |
| I. Introduction | |
Cell Line Name： | CSF3R T618I/BaF3 |
Host Cell: | Ba/F3 |
| Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
Application: | Anti-proliferation assay and PD assay |
Freeze Medium: | 90% FBS+10% DMSO |
Complete Culture Medium: | RPMI-1640+10%FBS |
Mycoplasma Status: | Negative |
| II.Background | |
CSF3R T618I lies within the extracellular domain proximal to the transmembrane domain of the Csf3r protein (PMID: 23656643). T618I confers a gain of function to the Csf3r protein as demonstrated by increased proliferation and increased downstream Jak-Stat signaling in transformed cells in culture (PMID: 23656643). | |
| III. Representative Data | |
1.WB of CSF3R T618I/BaF3
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2. Anti-proliferation assay | |
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Figure 2. Anti-proliferation assay of three reference compounds on the CSF3R T618I/BaF3. | |
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