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南京科佰生物科技有限公司

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EGFR L858R-T790M-C797S/BaF3

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產(chǎn)品型號CBP73049

品牌cobioer/科佰生物

廠商性質(zhì)代理商

所在地南京市

更新時間:2022-08-02 10:45:07瀏覽次數(shù):969次

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供貨周期 現(xiàn)貨 規(guī)格 T-25 Flask
貨號 CBP73049 應(yīng)用領(lǐng)域 生物產(chǎn)業(yè)
主要用途 僅限科研使用
EGFR L858R-T790M-C797S/BaF3,母細(xì)胞:BaF3,凍存條件:90% FBS+10% DMSO
CBP73049
I. Introduction

Cell Line Name:

EGFR L858R-T790M-C797S/BaF3

Host Cell:

Ba/F3

Stability:16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)

Application:

Anti-proliferation assay and PD assay

Freeze Medium:

90% FBS+10% DMSO

Complete Culture Medium:

RPMI-1640+10%FBS

Mycoplasma Status:

Negative


II.Background

EGFR is widely recognized for its importance in cancer. Amplification and mutations have been shown to be driving events in many cancer types. Its role in non-small cell lung cancer, glioblastoma and basal-like breast cancers has spurred many research and drug development efforts. Tyrosine kinase inhibitors have shown efficacy in EGFR amplfied tumors, most notably gefitinib and erlotinib. Mutations in EGFR have been shown to confer resistance to these drugs, particularly the variant T790M, which has been functionally characterized as a resistance marker for both of these drugs. The later generation TKI's have seen some success in treating these resistant cases, and targeted sequencing of the EGFR locus has become a common practice in treatment of non-small cell lung cancer. Overproduction of ligands is another possible mechanism of activation of EGFR. ERBB ligands include EGF, TGF-a, AREG, EPG, BTC, HB-EGF, EPR and NRG1-4 (for detailed information please refer to the respective ligand section). In ligand-activated cancers, Cetuximab appears to be more effective than tyrosine-kinase inhibitors.


III. Representative Data

1. WB of EGFR-L858R/T790M/C797S expression

CBP73049 WB.png

Figure 1. WB of EGFR Expression

Lane 1: Negative control

Lane 2: EGFR-WT

Lane 3: EGFR-L858R/T790M

Lane 4: EGFR-L858R/T790M/C797S

2. Sanger sequencing

CBP73049 sanger.png

Figure 2. Sanger Sequencing of EGFR-L858R/T790M/C797S

3. Anti-proliferation assay


CBP73049 數(shù)據(jù)圖.png

CBP73049 數(shù)據(jù)圖2.jpg


Figure 3. Anti-proliferation assay of three reference compounds on the EGFR L858R-T790M-C797S/BaF3 Stable Cell Line




CD74-ROS1 G2032R BaF3

CD74-ROS1 [G2032R] BaF3

CD74-ROS1 L2086F BaF3

CD74-ROS1 [L2086F] BaF3

KRAS G12D&Y96C BaF3

KRAS [G12D&Y96C] BaF3

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