The termination of protein synthesis is carried out by a variety of auxiliary factors that ensure the proper release of newly formed proteins. Once translation is complete, mRNA and P-site deacylated tRNA remain attached to the ribosome in a post-termination complex (post-TC) that must be dissociated and recycled in order for another round of translation to take place. MRRF (mitochondrial ribosome recycling factor), also known as RRF, MRFF or MTRRF, is a 262 amino acid protein that belongs to