| CBP73110 | |
| I. Introduction | |
Cell Line Name： | Her2 WT/BaF3 |
Host Cell: | Ba/F3 |
| Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
Application: | Anti-proliferation assay and PD assay |
Freeze Medium: | 90% FBS+10% DMSO |
Complete Culture Medium: | RPMI-1640+10% FBS |
Mycoplasma Status: | Negative |
| II.Background | |
ERBB2 (HER2), erb-b2 receptor tyrosine kinase 2, is an EGFR receptor tyrosine kinase that activates PI3K-AKT-mTOR and RAS-RAF-MEK-ERK pathways, therefore regulating growth and transformation (PMID: 17471238). ERBB2 (HER2) amplification, overexpression, and activation has been implicated in several tumor types (PMID: 17471238). | |
| III. Representative Data | |
1. WB of Her2 WT/BaF3
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2. Anti-proliferation assay | |
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Figure 2. Anti-proliferation assay of two reference compounds on the Ba/F3_HER2 WT Stable Cell line. | |
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